Responsiveness of osteoblastic and osteolytic bone metastases to vitamin D analogs.
Crit Rev Eukaryot Gene Expr
; 17(2): 149-58, 2007.
Article
en En
| MEDLINE
| ID: mdl-17725485
ABSTRACT
Bone is the primary site of metastases in advanced androgen-independent prostate cancer. These metastases are primarily bone-forming, although the presence of osteolytic response has also been reported. Bone-homing therapy is a strategy based on the popular seed-and-soil relationship between the epithelial malignant cells and the bone stroma. Calcitriol (1,25-dihydroxyvitamin D3) and its synthetic analogs (deltanoids) are drugs that have a direct effect on both the skeleton and the invading metastatic cells and, therefore, are considered useful in the treatment of advanced prostate cancer. In this article, I review the nature of the response induced by the malignant cells in the bone (bone formation or bone resorption) and how it affects the outcome of a vitamin D analog treatment in preclinical models of metastatic bone disease.
Search on Google
Banco de datos:
MEDLINE
Asunto principal:
Vitamina D
/
Neoplasias Óseas
Límite:
Animals
/
Humans
/
Male
Idioma:
En
Año:
2007
Tipo del documento:
Article