The efficacy of mezlocillin-amikacin combination in febrile neutropenic children with oncologic disease.
J Chemother
; 3(4): 250-4, 1991 Aug.
Article
en En
| MEDLINE
| ID: mdl-1779260
ABSTRACT
The efficacy of mexlocillin-amikacin combination as empirical therapy for febrile neutropenic patients was studied in 30 children (21 males, 9 females) with various oncologic diseases aged 1-15 years (mean age 7.3 +/- 4.4) in the Istanbul Medical School, Oncologic Disease Research and Treatment Center, and Department of Pediatric Hematology-Oncology between January 1 and May 31, 1988. The response rate was 76.6%. Profound persistent granulocytopenia (fewer than 100 ml) was present in 70% of the patients. In 63.3% of patients, the infections were microbiologically documented (60%) Gram(+) and 40% Gram(-). The combination was well tolerated with hepatic and/or renal disturbances in 8 cases (26.6%). We conclude that mezlocillin-amikacin is an effective empirical combination in the initial treatment of infections in febrile neutropenic children with various oncologic diseases.
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Banco de datos:
MEDLINE
Asunto principal:
Amicacina
/
Fiebre
/
Mezlocilina
/
Neoplasias
/
Neutropenia
Tipo de estudio:
Etiology_studies
Límite:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Idioma:
En
Año:
1991
Tipo del documento:
Article