Ovarian cancer: PCD and brain metastases.
Coll Antropol
; 31(2): 633-6, 2007 Jun.
Article
en En
| MEDLINE
| ID: mdl-17847951
ABSTRACT
Paraneoplastic cerebellar degeneration (PCD), the one of the most common paraneoplastic syndromes, refer to clinical disorders associated mostly with lung, ovarian and breast cancer, but not directly caused by the cancer or its metastases. Pathologic finding is an extensive loss of Purkinje cells in the cerebellum. Immunohistochemically, the auto-antibodies on the Purkinje cells had been detected. Clinically, PCD is characterized by sub-acutely evolving pancerebellar symptoms. Neurological dysfunction may appear before the detection of the underlying cancer. Therefore, the surgical exploration is necessary for the final diagnosis. The patient undergoes specific therapy. Soon, neurological status of the patient gets irreparable worse. Death come usually 2-3 years after the first symptoms of the PCD occurs. Case of a 63-years old woman with PCD as the first evidence of her cancer is reported. The patient developed brain metastases and died almost 3 years after the first symptoms of PCD occur
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Banco de datos:
MEDLINE
Asunto principal:
Neoplasias Ováricas
/
Neoplasias Encefálicas
/
Cistadenocarcinoma Seroso
/
Degeneración Cerebelosa Paraneoplásica
Límite:
Female
/
Humans
/
Middle aged
Idioma:
En
Año:
2007
Tipo del documento:
Article