Wnt pathway anomalies in developing amygdalae of Turner syndrome-like mice.
J Mol Neurosci
; 32(2): 111-9, 2007.
Article
en En
| MEDLINE
| ID: mdl-17873295
ABSTRACT
Certain neurobehavioral deficiencies associated with Turner Syndrome have been attributed to brain volumetric abnormalities, particularly of the amygdala. Haplo-insufficiency of a non-dosage compensated gene or genes on the X chromosome has been hypothesized to be the cause of the neuroanatomical defect. We examined gene expression levels of 6,628 genes in developing amygdalae of late-stage embryos of a mouse model for Turner Syndrome. In total, 161 genes show significant differences in expression level between TS and normal female amygdala. In silico pathway analysis of both X-linked and autosomal mis-regulated genes suggests that modulation of Wnt signaling is a critical factor in the normal growth and development of the amygdala.
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Banco de datos:
MEDLINE
Asunto principal:
Síndrome de Turner
/
Cromosoma X
/
Proteínas Wnt
/
Amígdala del Cerebelo
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Pregnancy
Idioma:
En
Año:
2007
Tipo del documento:
Article