Localization of alpha-synuclein to mitochondria within midbrain of mice.
Neuroreport
; 18(15): 1543-6, 2007 Oct 08.
Article
en En
| MEDLINE
| ID: mdl-17885598
ABSTRACT
The interrelationship between alpha-synuclein (alpha-syn) and mitochondria is not clearly understood. Owing to the lack of the signal peptide and its predominant localization in the cytosol, alpha-syn is generally considered to affect mitochondrial function through some secondary effects. Contrary to this assumption, here, we show that a portion of alpha-syn is present in the membrane of mitochondria in normal dopaminergic neurons. The same profile is also found in other alpha-syn-positive neurons. Thus, binding to the membrane of mitochondria is the physiological nature of alpha-syn and might also contribute to the pathological role of this protein in the mitochondrial dysfunction in Parkinson's disease.
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Banco de datos:
MEDLINE
Asunto principal:
Mesencéfalo
/
Alfa-Sinucleína
/
Mitocondrias
Límite:
Animals
Idioma:
En
Año:
2007
Tipo del documento:
Article