The immunology of rheumatoid arthritis.
Ann N Y Acad Sci
; 1108: 312-22, 2007 Jun.
Article
en En
| MEDLINE
| ID: mdl-17893995
ABSTRACT
Rheumatoid arthritis (RA) is represents the most common chronic inflammatory joint disease and is still a major medical challenge because of unsolved issues related to the etiologic and pathogenetic questions. Intensive research has been conducted over the last years that focused on the inappropriate activation of the immune system although T cells have long been deemed to play a central role in the origin and propagation of joint inflammation, data accumulated so far have widened this perspective recognizing the contribution of other cells, as well as the major histocompatibility complex class II proteins and a composite set of costimulatory signals responsible for the production of proinflammatory cytokines and other soluble mediators implicated in tissue destruction typical of the disease. This paper will provide an insight into the immune system in RA, dissecting cellular and humoral aspects both in serum and in synovium of patients.
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Banco de datos:
MEDLINE
Asunto principal:
Artritis Reumatoide
/
Transducción de Señal
Límite:
Humans
Idioma:
En
Año:
2007
Tipo del documento:
Article