Antisense activity of 2',4'-BNA targeted to PPAR gamma in THP-1 and HCT116 cells.
Nucleic Acids Symp Ser (Oxf)
; (51): 441-2, 2007.
Article
en En
| MEDLINE
| ID: mdl-18029776
ABSTRACT
2'-O,4'-C-methylene bridged nucleic acid (2',4'-BNA) is a nucleic acid analogue that has high affinity binding to its complementary RNA. Peroxisome proliferator-activated receptor (PPAR) y belongs to the nuclear hormone receptor superfamily and is a drug target in the treatment of type 2 diabetes. Here, we show the antisense effects of 2',4'-BNA oligonucleotides against PPARy in the human monocytic leukaemia cell line THP-1 and the human colorectal tumor cell line HCT116.
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Banco de datos:
MEDLINE
Asunto principal:
Oligonucleótidos Antisentido
/
PPAR gamma
/
Hipoglucemiantes
Límite:
Humans
Idioma:
En
Año:
2007
Tipo del documento:
Article