Effect of ambrein on blood glucose levels of rats.

ABSTRACT

Ambrein reduced the blood glucose level of normal and moderately alloxan-diabetic rats but did not reduce the blood glucose levels of severely-diabetic rats. Ambrein did not reduce the hyperglycemia of glucose-loaded rats also given mannoheptulose but it reduced the hyperglycemia of glucose-loaded rats in the absence of mannoheptulose. Results suggested that the hypoglycemic activity of ambrein may be mediated by enhanced glucose utilization.