Mitochondrial injury in pancreatitis.
Cell Calcium
; 44(1): 14-23, 2008 Jul.
Article
en En
| MEDLINE
| ID: mdl-18207570
ABSTRACT
Pancreatitis is an increasingly common disease that carries a significant mortality and which lacks specific therapy. Pathological calcium signalling is an important contributor to the initiating cell injury, caused by or acting through mitochondrial inhibition. A principal effect of disordered cell signalling and impaired mitochondrial function is cell death, either by apoptosis that is primarily protective, or by necrosis that is deleterious, both locally and systemically. Mitochondrial calcium overload is particularly important in necrotic injury, which may include damage mediated by the mitochondrial permeability transition pore. The role of reactive oxygen species remains controversial. Present understanding of the part played by disordered pancreatic acinar calcium signalling and mitochondrial inhibition offers several new potential therapeutic targets.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Páncreas
/
Pancreatitis
/
Muerte Celular
/
Señalización del Calcio
/
Mitocondrias
Tipo de estudio:
Etiology_studies
Límite:
Animals
/
Humans
Idioma:
En
Año:
2008
Tipo del documento:
Article