Study of manganese bacteriopheophorbide as a potential contrast agent for magnetic resonance tomography.

Meerovich, I G; Brandis, A; Meerovich, G A; Stratonnikov, A A; Bendel, P; Oborotova, N A; Shertz, A; Baryshnikov, A Yu

Meerovich, I G; Brandis, A; Meerovich, G A; Stratonnikov, A A; Bendel, P; Oborotova, N A; Shertz, A; Baryshnikov, A Yu.

Meerovich IG; N. N. Blokhin National Cancer Research Center, Russian Academy of Medical Sciences, Moscow. meerovich@mail.ru

Bull Exp Biol Med ; 143(4): 452-4, 2007 Apr.

Article en En | MEDLINE | ID: mdl-18214298

ABSTRACT

ABSTRACT

The use of manganese bacteriopheophorbide characterized by a high relaxation capacity and selectively accumulating in the tumor as a contrast agent for magnetic resonance tomography significantly improves tumor contrasting against the background of normal tissues. The pharmacokinetics and selectivity of accumulation were studied by diffuse reflection spectroscopy.

Asunto(s)

Bacterioclorofilas/química; Medios de Contraste/química; Imagen por Resonancia Magnética/métodos; Compuestos de Manganeso/química; Animales; Bacterioclorofilas/farmacocinética; Carcinoma de Ehrlich/diagnóstico por imagen; Carcinoma de Ehrlich/metabolismo; Carcinoma de Ehrlich/patología; Medios de Contraste/farmacocinética; Compuestos de Manganeso/farmacocinética; Ratones; Ratones Desnudos; Cintigrafía

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Banco de datos: MEDLINE Asunto principal: Bacterioclorofilas / Imagen por Resonancia Magnética / Compuestos de Manganeso / Medios de Contraste Límite: Animals Idioma: En Año: 2007 Tipo del documento: Article

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