CDK inhibitors: cell cycle regulators and beyond.
Dev Cell
; 14(2): 159-69, 2008 Feb.
Article
en En
| MEDLINE
| ID: mdl-18267085
ABSTRACT
First identified as cell cycle inhibitors mediating the growth inhibitory cues of upstream signaling pathways, the cyclin-CDK inhibitors of the Cip/Kip family p21Cip1, p27Kip1, and p57Kip2 have emerged as multifaceted proteins with functions beyond cell cycle regulation. In addition to regulating the cell cycle, Cip/Kip proteins play important roles in apoptosis, transcriptional regulation, cell fate determination, cell migration and cytoskeletal dynamics. A complex phosphorylation network modulates Cip/Kip protein functions by altering their subcellular localization, protein-protein interactions, and stability. These functions are essential for the maintenance of normal cell and tissue homeostasis, in processes ranging from embryonic development to tumor suppression.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Ciclo Celular
/
Proteínas Inhibidoras de las Quinasas Dependientes de la Ciclina
Límite:
Animals
/
Humans
Idioma:
En
Año:
2008
Tipo del documento:
Article