Engraftment and development of human T and B cells in mice after bone marrow transplantation.
Science
; 252(5004): 427-31, 1991 Apr 19.
Article
en En
| MEDLINE
| ID: mdl-1826797
ABSTRACT
A model for human lymphocyte ontogeny has been developed in a normal mouse. Human bone marrow, depleted of mature T and B lymphocytes, and bone marrow from mice with severe combined immunodeficiency were transplanted into lethally irradiated BALB/c mice. Human B and T cells were first detected 2 to 4 months after transplantation and persisted for at least 6 months. Most human thymocytes (30 to 50 percent of total thymocytes) were CD3+CD4+CD8+. Human immunoglobulin was detected in some chimeras, and a human antibody response to dinitrophenol could be generated after primary and secondary immunization.
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Banco de datos:
MEDLINE
Asunto principal:
Trasplante Heterólogo
/
Células de la Médula Ósea
/
Linfocitos B
/
Linfocitos T
/
Trasplante de Médula Ósea
Límite:
Animals
/
Humans
Idioma:
En
Año:
1991
Tipo del documento:
Article