PPARdelta is a type 1 IFN target gene and inhibits apoptosis in T cells.
J Invest Dermatol
; 128(8): 1940-9, 2008 Aug.
Article
en En
| MEDLINE
| ID: mdl-18305567
ABSTRACT
Peroxisome proliferator-activated receptor beta/delta (PPARdelta) is a nuclear hormone receptor regulating diverse biological processes, including beta-oxidation of fatty acid and epithelial cell differentiation. To date, the role of PPARdelta in the immune system has not been thoroughly studied. Here, we show that PPARdelta is expressed in activated human T cells purified from peripheral blood as well as in T cells isolated from affected psoriasis skin lesions. PPARdelta is induced in T cells on stimulation with type 1 IFN. Functionally, PPARdelta enhances proliferation of primary T cells and blocks apoptosis induced by type 1 IFN and by serum deprivation. We show that these cellular functions are mediated by the activation of extracellular signal-regulated kinase1/2 signaling. Our results (1) establish a direct molecular link between type 1 IFN signaling and PPARdelta, (2) define a functional role for PPARdelta in human T cells, and (3) suggest that the induction of PPARdelta by type 1 IFN contributes to the persistence of activated T cells in psoriasis skin lesions.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Linfocitos T
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Interferón Tipo I
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Apoptosis
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PPAR delta
Tipo de estudio:
Etiology_studies
Límite:
Humans
Idioma:
En
Año:
2008
Tipo del documento:
Article