Potent achiral agonists of the growth hormone secretagogue (ghrelin) receptor. Part 2: Lead optimisation.

Witherington, Jason; Abberley, Lee; Briggs, Michael A; Collis, Katharine; Dean, David K; Gaiba, Alessandra; King, N Paul; Kraus, Helmut; Shuker, Nicola; Steadman, Jon G A; Takle, Andrew K; Sanger, Gareth; Wadsworth, Graham; Butler, Sharon; McKay, Fiona; Muir, Alison; Winborn, Kim; Heightman, Tom D

Witherington, Jason; Abberley, Lee; Briggs, Michael A; Collis, Katharine; Dean, David K; Gaiba, Alessandra; King, N Paul; Kraus, Helmut; Shuker, Nicola; Steadman, Jon G A; Takle, Andrew K; Sanger, Gareth; Wadsworth, Graham; Butler, Sharon; McKay, Fiona; Muir, Alison; Winborn, Kim; Heightman, Tom D.

Witherington J; Department of Medicinal Chemistry & DMPK, Neurology & GI Centre of Excellence for Drug Discovery, GlaxoSmithKline, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK. Jason_Witherington@GSK.com

Bioorg Med Chem Lett ; 18(6): 2203-5, 2008 Mar 15.

Article en En | MEDLINE | ID: mdl-18316188

Asunto(s)

Indoles/farmacología; Receptores de Ghrelina/agonistas; Sulfonamidas/farmacología; Administración Oral; Animales; Disponibilidad Biológica; Fluorescencia; Indoles/síntesis química; Masculino; Estructura Molecular; Ratas; Ratas Sprague-Dawley; Receptor de Serotonina 5-HT1B/metabolismo; Receptores de Ghrelina/metabolismo; Relación Estructura-Actividad; Sulfonamidas/síntesis química

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Sulfonamidas / Receptores de Ghrelina / Indoles Límite: Animals Idioma: En Año: 2008 Tipo del documento: Article

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