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Elimination of wild-type P53 mRNA in glioblastomas showing heterozygous mutations of P53.
Szybka, M; Zawlik, I; Kulczycka, D; Golanska, E; Jesien, E; Kupnicka, D; Stawski, R; Piaskowski, S; Bieniek, E; Zakrzewska, M; Kordek, R; Liberski, P P; Rieske, P.
  • Szybka M; Department of Pathology, Medical University of Lodz, Paderewskiego 4, Lodz 93-509, Poland.
Br J Cancer ; 98(8): 1431-3, 2008 Apr 22.
Article en En | MEDLINE | ID: mdl-18349850
ABSTRACT
We screened 50 glioblastomas for P53 mutations. Five glioblastomas showed heterozygous mutations, while three were putatively heterozygous. Six of these eight glioblastomas showed elimination of wild-type P53 mRNA. These results strongly suggest that some sort of mechanism(s) favouring mutated over wild-type P53 mRNA exists in glioblastoma cells with heterozygous mutations of this gene.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / ARN Mensajero / Genes p53 / Proteína p53 Supresora de Tumor / Glioblastoma / Mutación Límite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Año: 2008 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / ARN Mensajero / Genes p53 / Proteína p53 Supresora de Tumor / Glioblastoma / Mutación Límite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Año: 2008 Tipo del documento: Article