Detailed 1H and 13C NMR structural assignment and relative stereochemistry determination for three closely related sesquiterpene lactones.
Magn Reson Chem
; 46(6): 576-81, 2008 Jun.
Article
en En
| MEDLINE
| ID: mdl-18357570
ABSTRACT
A complete analysis of (1)H and (13)C NMR spectra of the trypanocidal sesquiterpene lactone eremantholide C and two of its analogues is described. These structurally similar sesquiterpene lactones were submitted to (1)H NMR, (13)C {(1)H} NMR, gCOSY, gHSQC, gHMBC, J-resolved and DPFGSE-NOE NMR techniques. The detailed analysis of those results, correlated to some computational calculations (molecular mechanics), led to the total and unequivocal assignment of all (1)H and (13)C NMR data. The determination of all (1)H/(1)H coupling constants and all signal multiplicities, together with the elimination of previous ambiguities were also achieved.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Sesquiterpenos
/
Espectroscopía de Resonancia Magnética
/
Lactonas
Idioma:
En
Año:
2008
Tipo del documento:
Article