DNA base excision repair activities in mouse models of Alzheimer's disease.
Neurobiol Aging
; 30(12): 2080-1, 2009 Dec.
Article
en En
| MEDLINE
| ID: mdl-18378358
ABSTRACT
Alzheimer's disease (AD) has been correlated with elevated levels of oxidative DNA damage. Base excision repair (BER) is the main repair pathway for the removal of oxidative DNA base modifications. We have recently found significant functional deficiencies in BER in brains of sporadic AD and amnestic mild cognitive impairment patients. In this study we tested whether altered BER activities are associated with appearance of symptoms in different brain regions of pre-symptomatic and symptomatic mice harboring mutant APP alone or in combination with Tau and PS1. Our results suggest that unlike in humans, the development of AD-like pathology in the studied mouse models is not associated with deficiencies in BER.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Encéfalo
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ADN
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Reparación del ADN
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Enfermedad de Alzheimer
Límite:
Animals
Idioma:
En
Año:
2009
Tipo del documento:
Article