Prospective analysis of TEL gene rearrangements in childhood acute lymphoblastic leukemia: a Children's Oncology Group study.
J Clin Oncol
; 26(13): 2186-91, 2008 May 01.
Article
en En
| MEDLINE
| ID: mdl-18445843
ABSTRACT
PURPOSE:
To prospectively determine the prognostic significance of the TEL-AML1 fusion in children with acute lymphoblastic leukemia (ALL). PATIENTS ANDMETHODS:
TEL gene status was determined for 926 patients with B-precursor ALL enrolled on the Pediatric Oncology Group ALinC 16 trials and patients were observed for a median time of 8 years.RESULTS:
Rearrangements of the TEL gene were detected in 244 patients (26%). The estimated 5-year event-free survival rate (+/- SE) for patients with TEL rearrangements was 86% +/- 2%, compared with 72% +/- 2% for those with germline TEL (P < .0001). TEL rearrangements were associated with a superior outcome among patients with standard-risk ALL, high-risk ALL, and rapid early responses to therapy. In a multivariate analysis that included risk group, sex, and day 15 marrow status, TEL status was an independent predictor of outcome (P = .0002).CONCLUSION:
We conclude that TEL gene status should be incorporated into risk classification schemes and suggest that patients who have standard-risk features, the TEL-AML1 fusion, and rapid early responses to therapy, should be treated with antimetabolite-based therapy designed to maintain their high cure rates and avoid late effects.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Reordenamiento Génico
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Leucemia-Linfoma Linfoblástico de Células Precursoras B
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Regulación Leucémica de la Expresión Génica
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Proteínas de Fusión Oncogénica
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Subunidad alfa 2 del Factor de Unión al Sitio Principal
Tipo de estudio:
Clinical_trials
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Etiology_studies
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Observational_studies
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Prognostic_studies
/
Risk_factors_studies
Límite:
Adolescent
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Adult
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Child
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Child, preschool
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Female
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Humans
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Infant
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Male
País como asunto:
America do norte
Idioma:
En
Año:
2008
Tipo del documento:
Article