Pyrrolo[1,2-b]pyridazin-2-ones as potent inhibitors of HCV NS5B polymerase.
Bioorg Med Chem Lett
; 18(12): 3616-21, 2008 Jun 15.
Article
en En
| MEDLINE
| ID: mdl-18487044
ABSTRACT
Pyrrolo[1,2-b]pyridazin-2-one analogs were discovered as a novel class of inhibitors of genotype 1 HCV NS5B polymerase. Structure-based design led to the discovery of compound 3 k, which displayed potent inhibitory activities in biochemical and replicon assays (IC(50) (1b)<10nM; EC(50) (1b)=12 nM) as well as good stability towards human liver microsomes (HLM t(1/2)>60 min).
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Antivirales
/
Piridazinas
/
Pirroles
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Proteínas no Estructurales Virales
Límite:
Animals
/
Humans
Idioma:
En
Año:
2008
Tipo del documento:
Article