Short-term sevoflurane sedation using the Anaesthetic Conserving Device after cardiothoracic surgery.
Intensive Care Med
; 34(9): 1683-9, 2008 Sep.
Article
en En
| MEDLINE
| ID: mdl-18500419
ABSTRACT
OBJECTIVE:
We evaluated the procedure of postoperative inhalational sedation with sevoflurane using the Anaesthetic Conserving Device (ACD) with regard to recovery times, feasibility and consumption of anaesthetics in comparison to propofol. DESIGN ANDSETTING:
Prospective, randomised, single-blinded, controlled study in a surgical intensive care unit (ICU) of a 1,000-bed academic hospital. PATIENTS ANDINTERVENTIONS:
A total of 70 patients after elective coronary artery bypass graft surgery either received sevoflurane via ACD (n = 35) or propofol (n = 35) for short-term postoperative sedation in the ICU. MEASUREMENTS AND MAINRESULTS:
The primary endpoint was extubation time from termination of sedation. Recovery times, consumption of anaesthetics, endtidal sevoflurane concentrations, length of ICU and hospital stay, and side effects were documented. Mean recovery times were significantly shorter with sevoflurane than with propofol (extubation time 22 vs. 151 min; following commands 7 vs. 42 min). The mean (SD) sevoflurane consumption was 3.2 +/- 1.4 mL/h to obtain mean endtidal concentrations of 0.76 vol%. No serious complications occurred during sedation with either sedative drug. The length of ICU stay was comparable in both groups, but hospital length of stay was significantly shorter in the sevoflurane group. Drug costs (in Euro) for sedation per patient were similar in both groups (sevoflurane 15.1 +/- 9.5CONCLUSIONS:
Sevoflurane administration via ACD is an effective and safe alternative to propofol to provide postoperative short-term ICU sedation. Recovery from sedation was facilitated with sevoflurane instead of propofol and resulted in shorter extubation and ventilator times. DESCRIPTOR Neurology/sedation, Sedation and anaesthesia.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Propofol
/
Anestésicos Intravenosos
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Anestésicos por Inhalación
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Sedación Profunda
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Anestesiología
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Éteres Metílicos
Tipo de estudio:
Clinical_trials
Límite:
Aged
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Female
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Humans
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Male
/
Middle aged
Idioma:
En
Año:
2008
Tipo del documento:
Article