Synthesis of bis, tris and tetra(dihydrocaffeoyl)polyamine conjugates as antibacterial agents against VRSA.
Arch Pharm Res
; 31(6): 698-704, 2008 Jun.
Article
en En
| MEDLINE
| ID: mdl-18563350
ABSTRACT
Bis, tris and tetra(dihydrocaffeoyl)polyamine conjugates were synthesized using solid phase synthesis technique. These compounds were screened for antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) (11 strains) and vancomycin-resistant S. aureus (VRSA) (4 strains). Bis, tris and tetra(dihydrocaffeoyl)polyamine analogues showed antibacterial activity against VRSA which were better than the reference drugs, vancomycin. Tetra(dihydrocaffeoyl)polyamine conjugate exhibited the highest activity. These compounds showed no cytotoxicity against vero cells.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Staphylococcus aureus
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Ácidos Cafeicos
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Espermidina
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Resistencia a la Meticilina
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Resistencia a la Vancomicina
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Antibacterianos
Límite:
Animals
Idioma:
En
Año:
2008
Tipo del documento:
Article