Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus.
Nat Genet
; 40(9): 1092-7, 2008 Sep.
Article
en En
| MEDLINE
| ID: mdl-18711367
ABSTRACT
We carried out a multistage genome-wide association study of type 2 diabetes mellitus in Japanese individuals, with a total of 1,612 cases and 1,424 controls and 100,000 SNPs. The most significant association was obtained with SNPs in KCNQ1, and dense mapping within the gene revealed that rs2237892 in intron 15 showed the lowest Pvalue (6.7 x 10(-13), odds ratio (OR) = 1.49). The association of KCNQ1 with type 2 diabetes was replicated in populations of Korean, Chinese and European ancestry as well as in two independent Japanese populations, and meta-analysis with a total of 19,930 individuals (9,569 cases and 10,361 controls) yielded a P value of 1.7 x 10(-42) (OR = 1.40; 95% CI = 1.34-1.47) for rs2237892. Among control subjects, the risk allele of this polymorphism was associated with impairment of insulin secretion according to the homeostasis model assessment of beta-cell function or the corrected insulin response. Our data thus implicate KCNQ1 as a diabetes susceptibility gene in groups of different ancestries.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Polimorfismo de Nucleótido Simple
/
Diabetes Mellitus Tipo 2
/
Canal de Potasio KCNQ1
Tipo de estudio:
Risk_factors_studies
Límite:
Humans
Idioma:
En
Año:
2008
Tipo del documento:
Article