Transfusion-related acute lung injury (TRALI) during remission induction course of acute myeloid leukemia: a possible role for all-transretinoic-acid (ATRA)?
Pathol Biol (Paris)
; 57(6): 500-2, 2009 Sep.
Article
en En
| MEDLINE
| ID: mdl-18823719
ABSTRACT
Transfusion-related acute lung injury (TRALI) is a clinical syndrome characterized by sudden onset of respiratory distress due to pulmonary edema during or following transfusion. Two proposed pathophysiologic mechanisms for TRALI were proposed the antibody hypothesis and the two-event hypothesis. The two-event hypothesis postulates that a pathway to neutrophil activation and aggregation can occur without leukocyte antibodies. We report a case of TRALI occurring during remission induction course of acute myeloid leukemia in a 27-year-old woman who received All-transretinoic-acid (ATRA). We postulate that ATRA may have played a role in this life-threatening complication by priming neutrophil and enhancing their adherence and their activation in the pulmonary endothelium. TRALI improved with non-invasive ventilation support and use of high dose corticosteroids.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Tretinoina
/
Leucemia Mieloide Aguda
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Reacción a la Transfusión
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Leucocitosis
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Antineoplásicos
Tipo de estudio:
Etiology_studies
Límite:
Adult
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Female
/
Humans
Idioma:
En
Año:
2009
Tipo del documento:
Article