Chemical individuality: concept and outlook.
J Inherit Metab Dis
; 31(5): 630-40, 2008 Oct.
Article
en En
| MEDLINE
| ID: mdl-18836888
ABSTRACT
Sir Archibald Garrod's concept of chemical individuality introduced a century ago provided the basis for the entire discipline of inborn errors of metabolism. Human disorders are defined by variation in disease-causing mutations, environmental influences, genetic factors other than the primary genetic defect, and evolution itself. Myriad examples support the prescience of Garrod with respect to these issues, each of which has therapeutic implications. Just as Garrod predicted that the future of biochemical genetics would be intertwined with the concept of chemical variability, we might forecast that variation will influence emotions, dreams, and the human thinking process itself.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Errores Innatos del Metabolismo
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Año:
2008
Tipo del documento:
Article