[Effect of mycophenolate mofetil on the expression of early inflammatory reaction in diabetic rats].
Zhong Nan Da Xue Xue Bao Yi Xue Ban
; 33(10): 913-8, 2008 Oct.
Article
en Zh
| MEDLINE
| ID: mdl-19001733
ABSTRACT
OBJECTIVE:
To investigate the effect of mycophenolate mofetil(MMF) on early inflammatory reaction of renal lesion in streptozotocin(STZ)-induced diabetic rats.METHODS:
Thirty-six male Sprague-Dawley rats were randomly divided into 3 groups after uninephrectomy normal control group, diabetic model group, and MMF-treated group. Six rats in each group were sacrificed at the 4th week and 14th week after STZ injection. Twenty-four hour urinary protein (24 h Upro) count was measured before death. The expressions of regulated on activation of normal T expressed and secreted (RANTES),ectodermal dysplasia (ED-1)and Col-IV protein in the renal tissue were detected by immunohistochemistry. The expression of RANTES mRNA in the renal tissue was detected by RT-PCR.RESULTS:
MMF prevented the increasing of 24h Upro in diabetic rats,and the expressions of RANTES,ED-1,Col-IV protein and RANTES mRNA in the kidney of MMF-treated rats were significantly decreased.CONCLUSION:
MMF plays an early renal protective role in diabetic nephropathy, possibly through inhibition of early inflammatory reaction.
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Banco de datos:
MEDLINE
Asunto principal:
Quimiocina CCL5
/
Diabetes Mellitus Experimental
/
Nefropatías Diabéticas
/
Ectodisplasinas
/
Ácido Micofenólico
Límite:
Animals
Idioma:
Zh
Año:
2008
Tipo del documento:
Article