Immaturity and aneuploidy in human oocytes after different stimulation protocols.
Fertil Steril
; 56(2): 306-10, 1991 Aug.
Article
en En
| MEDLINE
| ID: mdl-1906409
ABSTRACT
OBJECTIVE:
To study immaturity and aneuploidy in human oocytes after two different stimulation protocols.DESIGN:
Retrospective.SETTING:
Outpatient IVF clinic/laboratory. PATIENTS One hundred forty-three patients of whom 65 were stimulated with clomiphene citrate (CC)/human menopausal gonadotropin (hMG) and 78 were stimulated with gonadotropin-releasing hormone agonist (GnRH-a)/hMG. Only patients with at least one oocyte unfertilized were included in this study.RESULTS:
Stimulation with GnRH-a/hMG, as compared with CC/hMG stimulation, resulted in larger numbers of oocytes (P less than 0.00001), a higher fertilization rate (P less than 0.02), and oocyte retrieval at a later average cycle day (P less than 0.000005). Cytogenetic findings of immaturity were observed in 33.9% of unfertilized oocytes after CC/hMG stimulation, compared with only 17.8% after GnRH-a/hMG stimulation (P less than 0.0005). Aneuploidy findings were the same for both groups.CONCLUSION:
In GnRH-a/hMG stimulation, oocytes approach the normal day of ovulation more closely. This may allow for better oocyte maturation and higher fertilization and pregnancy rates.
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Banco de datos:
MEDLINE
Asunto principal:
Oocitos
/
Inducción de la Ovulación
Tipo de estudio:
Guideline
/
Observational_studies
Límite:
Female
/
Humans
/
Pregnancy
Idioma:
En
Año:
1991
Tipo del documento:
Article