[Clinical and genetic features in patients with asthma and their relatives].
Probl Tuberk Bolezn Legk
; (9): 47-50, 2008.
Article
en Ru
| MEDLINE
| ID: mdl-19065735
ABSTRACT
A familial survey was conducted in 81 probands who were diagnosed as having bronchial asthma (BA) and their 183 first-, second-, and third-degree relatives (a study group). A control group comprised 263 apparently healthy individuals. The familial accumulation of BA was ascertained in the families of probands with this condition. Autosomal dominant inheritance of BA was established. The heterozygous variant of the macrophage-colony-stimulating factor receptor (MCSFR) gene genotype chi-fms may be considered as one of the genetic predictors of BA. The homozygous genotype in a rare allele of the MCSFR gene may be also a predictor of BA.
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Banco de datos:
MEDLINE
Asunto principal:
Asma
/
Genotipo
Tipo de estudio:
Prognostic_studies
Límite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Ru
Año:
2008
Tipo del documento:
Article