Interferon-gamma and tumour necrosis factor induce expression of major histocompatibility complex antigen on rat retinal astrocytes.
Br J Ophthalmol
; 75(8): 473-5, 1991 Aug.
Article
en En
| MEDLINE
| ID: mdl-1908315
ABSTRACT
Cultured rat retinal astrocytes were tested by indirect immunofluorescence staining for their ability to express class I and II major histocompatibility complex (MHC) antigens under basal culture conditions and after three days of stimulation with two recombinant cytokines, rat interferon-gamma (IFN-gamma) and human tumour necrosis factor alpha (TNF alpha). Under basal culture conditions low levels of class I antigens were detected on a small percentage of cells, but there was no visible class II. IFN-gamma and TNF alpha stimulation enhanced class I expression. TNF alpha had no effect on class II expression, whereas IFN-gamma induced the expression of class II in a dose dependent manner. These findings suggest that retinal astrocytes might play a part in immunological events occurring in the retina.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Antígenos de Histocompatibilidad Clase I
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Antígenos de Histocompatibilidad Clase II
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Astrocitos
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Interferón gamma
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Factor de Necrosis Tumoral alfa
Límite:
Animals
Idioma:
En
Año:
1991
Tipo del documento:
Article