Gag p27-specific B- and T-cell responses in Simian immunodeficiency virus SIVagm-infected African green monkeys.
J Virol
; 83(6): 2770-7, 2009 Mar.
Article
en En
| MEDLINE
| ID: mdl-19109377
ABSTRACT
Nonpathogenic simian immunodeficiency virus SIVagm infection of African green monkeys (AGMs) is characterized by the absence of a robust antibody response against Gag p27. To determine if this is accompanied by a selective loss of T-cell responses to Gag p27, we studied CD4(+) and CD8(+) T-cell responses against Gag p27 and other SIVagm antigens in the peripheral blood and lymph nodes of acutely and chronically infected AGMs. Our data show that AGMs can mount a T-cell response against Gag p27, indicating that the absence of anti-p27 antibodies is not due to the absence of Gag p27-specific T cells.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Linfocitos B
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Linfocitos T CD4-Positivos
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Productos del Gen gag
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Síndrome de Inmunodeficiencia Adquirida del Simio
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Virus de la Inmunodeficiencia de los Simios
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Linfocitos T CD8-positivos
Límite:
Animals
Idioma:
En
Año:
2009
Tipo del documento:
Article