Relationship between oxidized fibrinogen and hemostasis disturbances and endothelial dysfunction in myocardial infarction.
Bull Exp Biol Med
; 145(4): 412-4, 2008 Apr.
Article
en En
| MEDLINE
| ID: mdl-19110580
ABSTRACT
Oxidative modification of fibrinogen in acute myocardial infarction increased 1.3-fold compared to that in CHD and 1.5-fold surpassed that in the control without CHD. Elevated content of oxidized fibrinogen correlated with increased levels of LPO products, von Willebrand factor, and fibrin degradation products, with accelerated leukocyte and platelet aggregation, and reduced content of NO metabolites in the plasma. Independent associations of oxidized fibrinogen with myocardial infarction and typical thrombogenic and hypercoagulation hemostasis disorders and endothelial dysfunctions were revealed.
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Banco de datos:
MEDLINE
Asunto principal:
Enfermedades Vasculares
/
Trastornos de la Coagulación Sanguínea
/
Fibrinógeno
/
Endotelio Vascular
/
Hemostasis
/
Infarto del Miocardio
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Adult
/
Aged
/
Humans
/
Male
/
Middle aged
Idioma:
En
Año:
2008
Tipo del documento:
Article