Structural and calorimetrical studies of the effect of different aminoglycosides on DPPC liposomes.
Colloids Surf B Biointerfaces
; 69(1): 116-21, 2009 Feb 15.
Article
en En
| MEDLINE
| ID: mdl-19118988
ABSTRACT
The effects of tobramycin, spectinomycin and streptomycin on 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC)/water vesicle system were studied by using differential scanning calorimetry (DSC) and simultaneous small- and wide-angle X-ray scattering (SWAXS) in the 0-1 lipid/aminoglycoside molar range. The changes in enthalpy between the thermally adjacent phases are decreased, but the pace of decrease is totally different for the three investigated AGs. The alterations in the lamellar arrangement and the chain packing are rather tendentious and are extended by increased AG concentrations depending on the type of the AG. In the case of tobramycin and streptomycin, still sharp Bragg peaks of SAXS curves shift to smaller values of the scattering variable, while spectinomycin results in an entire loss of multilayer correlation representing an increased amount of unbound bilayers.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
1,2-Dipalmitoilfosfatidilcolina
/
Aminoglicósidos
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Liposomas
Idioma:
En
Año:
2009
Tipo del documento:
Article