Whole-genome conditional two-locus analysis identifies novel candidate genes for late-onset Parkinson's disease.
Neurogenetics
; 10(3): 173-81, 2009 Jul.
Article
en En
| MEDLINE
| ID: mdl-19156451
ABSTRACT
Whole-genome epistasis analysis may add a new layer of knowledge to whole-genome association studies, permitting the identification of new candidate genes which are completely transparent during conventional single-locus analysis. We present the first whole-genome conditional two-locus analysis in Parkinson's disease (PD). We scanned the entire genome and selected markers that interacted with a set of well-known loci previously associated to PD (SNCA, Parkin, LRRK2, UCHL1, DJ-1, PINK and MAPT). Our work describes several loci potentially related to PD risk which interact with SNCA, PARK1 and LRRK2 markers. We propose conditional whole-genome two-locus association analysis as a valuable method that might be helpful in re-analysing and re-interpreting data from whole-genome association studies.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Enfermedad de Parkinson
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Genoma
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Predisposición Genética a la Enfermedad
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Estudio de Asociación del Genoma Completo
Límite:
Adult
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Aged
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Aged80
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Humans
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Middle aged
Idioma:
En
Año:
2009
Tipo del documento:
Article