Selectivity in ligand recognition of G-quadruplex loops.
Biochemistry
; 48(8): 1675-80, 2009 Mar 03.
Article
en En
| MEDLINE
| ID: mdl-19173611
ABSTRACT
A series of disubstituted acridine ligands have been cocrystallized with a bimolecular DNA G-quadruplex. The ligands have a range of cyclic amino end groups of varying size. The crystal structures show that the diagonal loop in this quadruplex results in a large cavity for these groups, in contrast to the steric constraints imposed by propeller loops in human telomeric quadruplexes. We conclude that the nature of the loop has a significant influence on ligand selectivity for particular quadruplex folds.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
G-Cuádruplex
/
Conformación de Ácido Nucleico
Idioma:
En
Año:
2009
Tipo del documento:
Article