Docetaxel for metastatic breast cancer: two consecutive phase II trials.
Anticancer Res
; 28(6B): 3993-5, 2008.
Article
en En
| MEDLINE
| ID: mdl-19192662
ABSTRACT
BACKGROUND:
Docetaxel is the most active agent for metastatic breast cancer, but the optimal treatment regimen as a single agent has yet to be defined. PATIENTS ANDMETHODS:
Two consecutive monocentric phase II trials of docetaxel in metastatic breast cancer were carried out. In Trial I, 36 patients received docetaxel 35 mg/m2 weekly for 6 weeks every 8 weeks and in Trial II, 29 patients received docetaxel 100 mg/m2 day 1 every 21 days.RESULTS:
Patient characteristics were comparable. However, patients with liver involvement comprised 25% of cases in Trial I and 55% in Trial II. The overall response rate on an intention-to-treat basis was 19% vs. 45% in Trial I and II respectively; time to progression was 3.8 vs. 7.5 months respectively, and overall median survival was comparable in each trial.CONCLUSION:
Docetaxel given at 100 mg/m2 every three weeks appears to be a safe, effective regimen that can be applied in common clinical practice for the treatment of metastatic breast cancer.
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Banco de datos:
MEDLINE
Asunto principal:
Neoplasias de la Mama
/
Taxoides
/
Antineoplásicos
Límite:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Middle aged
Idioma:
En
Año:
2008
Tipo del documento:
Article