[Neoplastic angiogenesis]. / Angiogénesis neoplásica.
An Med Interna
; 25(7): 366-9, 2008 Jul.
Article
en Es
| MEDLINE
| ID: mdl-19296000
ABSTRACT
Neoplastic angiogenesis is an essential process in the progressive growth of neoplasms and the production of metastasis. Angiogenesis consists of a series of linked and sequential steps that ultimately leads to the development of a neovascular blood supply to the tumor mass. VEGF has got an essential role in neoplastic angiogenesis, therefore it is an important target in the treatment of neoplasms. Bevacizumab, a humanized monoclonal antibody, inhibits VEGF, and may also improve the delivery of chemotherapy to the tumor mass. Multi-kinase ihibitors (sorafenib and sunitinib) are orally administered small-molecules, that inhibit different receptors (essentials in the neoplastic angiogenesis), such as the VEGFR or PDGFR. These agents are useful in the treatment of advanced renal-cell carcinoma, and are under investigation in several tumors.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias
Límite:
Humans
Idioma:
Es
Año:
2008
Tipo del documento:
Article