12-Substituted 2,3-dimethoxy-8,9-methylenedioxybenzo[i]phenanthridines as novel topoisomerase I-targeting antitumor agents.
Bioorg Med Chem
; 17(7): 2877-85, 2009 Apr 01.
Article
en En
| MEDLINE
| ID: mdl-19303306
ABSTRACT
2,3-Dimethoxy-8,9-methylenedioxybenzo[i]phenanthridine and a few of its 12-substituted analogs are active as TOP1-targeting agents. Studies were performed to further evaluate the potential of this series of non-camptothecin TOP1-targeting agents. The influence of a hydroxymethyl, formyl, N,N-dimethylaminomethyl, 2-(N,N-dimethylamino)ethyl, 3-(N,N-dimethylamino)propyl), and 4-(N,N-dimethylamino)butyl substituent at the 12-position on TOP1-targeting activity and tumor cell growth was evaluated. In addition, the relative pharmacologic activities of the 12-carboxamide analog, as well as its N-methyl and N,N-dimethyl derivatives were assessed.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Fenantridinas
/
Inhibidores de Topoisomerasa I
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Antineoplásicos
Límite:
Humans
Idioma:
En
Año:
2009
Tipo del documento:
Article