Evidence for an ancestral core structure in nucleotide-binding proteins with the type A motif.
J Mol Biol
; 221(3): 751-4, 1991 Oct 05.
Article
en En
| MEDLINE
| ID: mdl-1942027
ABSTRACT
Many proteins that bind purine nucleotide triphosphates have a type A sequence motif. Only two classes of structures for such proteins are so far available from X-ray crystallography. We examined the tertiary structures of representatives of the two classes, porcine cytoplasmic adenylate kinase and Escherichia coli translational elongation factor Tu. Comparison of the two proteins suggests that the A motif may be just one part of a larger common core structure consisting of four parallel strands of beta-sheet sandwiched between four alpha-helices. This compact core structure comprises over one half of each protein. We speculate that A motif proteins have diverged from a common ancestor having this core structure.
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Banco de datos:
MEDLINE
Asunto principal:
Proteínas Portadoras
/
Adenilato Quinasa
/
Factor Tu de Elongación Peptídica
/
Proteína Receptora de AMP Cíclico
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Año:
1991
Tipo del documento:
Article