Dissection of the sequence-specific DNA binding and exonuclease  activities reveals a superactive yet apoptotically impaired mutant p53  protein.

Ahn, Jinwoo; Poyurovsky, Masha V; Baptiste, Nicole; Beckerman, Rachel; Cain, Christine; Mattia, Melissa; McKinney, Kristine; Zhou, Jianmin; Zupnick, Andrew; Gottifredi, Vanesa; Prives, Carol

Dissection of the sequence-specific DNA binding and exonuclease activities reveals a superactive yet apoptotically impaired mutant p53 protein.

Ahn, Jinwoo; Poyurovsky, Masha V; Baptiste, Nicole; Beckerman, Rachel; Cain, Christine; Mattia, Melissa; McKinney, Kristine; Zhou, Jianmin; Zupnick, Andrew; Gottifredi, Vanesa; Prives, Carol.

Ahn J; Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Cell Cycle ; 8(10): 1603-15, 2009 May 15.

Article en En | MEDLINE | ID: mdl-19462533

Asunto(s)

Apoptosis; ADN/metabolismo; Exonucleasas/metabolismo; Proteína p53 Supresora de Tumor/metabolismo; Secuencia de Bases; Ciclo Celular; Línea Celular; Activación Enzimática; Humanos; Mutación/genética; Unión Proteica; Proteína p53 Supresora de Tumor/genética

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: ADN / Proteína p53 Supresora de Tumor / Apoptosis / Exonucleasas Límite: Humans Idioma: En Año: 2009 Tipo del documento: Article

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