Diaminocyclobutenediones as potent and orally bioavailable CXCR2 receptor antagonists: SAR in the phenolic amide region.
Bioorg Med Chem Lett
; 19(15): 4446-9, 2009 Aug 01.
Article
en En
| MEDLINE
| ID: mdl-19525110
ABSTRACT
A series of potent and orally bioavailable 3,4-diaminocyclobutenediones with various amide modifications and substitution on the left side phenyl ring were prepared and found to show significant inhibitory activities towards both CXCR2 and CXCR1 receptors.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Fenol
/
Ciclobutanos
/
Receptores de Interleucina-8A
/
Receptores de Interleucina-8B
/
Diaminas
/
Amidas
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Año:
2009
Tipo del documento:
Article