MicroRNAs and immune regulatory T cells.
Int Immunopharmacol
; 9(5): 524-7, 2009 May.
Article
en En
| MEDLINE
| ID: mdl-19539573
ABSTRACT
MicroRNAs (miRNAs)-mediated RNA interference are emerging as an important regulatory pathway for various biological processes, including development, differentiation, and homeostasis. Accumulated evidence suggests that miRNAs regulate T cell and B cell differentiation, proliferation, and apoptosis. Deletion of miRNAs in hematopoietic stem cells or in thymus disrupts T cell homeostasis and results in autoimmunity and abnormal cytokine production. Regulatory T cells are potent immune regulators. In this mini-review, we provide a brief overview of the important roles of miRNAs in the development and function of T cells, especially in immune regulatory T cells.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Linfocitos B
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Linfocitos T Reguladores
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MicroARNs
Límite:
Animals
/
Humans
Idioma:
En
Año:
2009
Tipo del documento:
Article