Synthesis of 3-N-sugar-substituted-2, 4(1H,3H)-quinazolinedionesas anti-angiogenesis agents.

Huang, Conghai; Meng, Xiangbao; Cui, Jingrong; Li, Zhongjun

Huang, Conghai; Meng, Xiangbao; Cui, Jingrong; Li, Zhongjun.

Huang C; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China. michaelhchh@gmail.com

Molecules ; 14(7): 2447-57, 2009 Jul 08.

Article en En | MEDLINE | ID: mdl-19633615

ABSTRACT

ABSTRACT

A series of novel 3-N-sugar-substituted quinazolinediones were synthesizedthrough the cyclization of the intermediate 2-aminobenzamides using triphosgene as the condensing reagent. Their anti-angiogenesis activities were investigated. The compound 3-(2'-aminoglucosyl)-2,4-(1H,3H)-quinazolinedione, (5d) showed good anti-angiogenesis activity.

Asunto(s)

Inhibidores de la Angiogénesis/síntesis química; Quinazolinonas/síntesis química; Inhibidores de la Angiogénesis/química; Inhibidores de la Angiogénesis/farmacología; Animales; Embrión de Pollo; Ciclización; Neovascularización Fisiológica/efectos de los fármacos; Fosgeno/análogos & derivados; Fosgeno/química; Quinazolinonas/química; Quinazolinonas/farmacología; ortoaminobenzoatos/química

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Inhibidores de la Angiogénesis / Quinazolinonas Límite: Animals Idioma: En Año: 2009 Tipo del documento: Article

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