A case of pediatric virilizing adrenocortical tumor resulting in hypothalamic-pituitary activation and central precocious puberty following surgical removal.
Endocr J
; 56(8): 975-82, 2009.
Article
en En
| MEDLINE
| ID: mdl-19671995
ABSTRACT
We present a 6-year-old boy with a virilizing adrenocortical tumor who initially presented with peripheral precocious puberty. Development of facial acne, pubic hair and a growth spurt were noted at the age of five. A low-pitched voice as well as maturation of external genitalia was noted at the age of six. Both serum and urinary levels of adrenal androgens were elevated. Abdominal computed tomography revealed a large right suprarenal mass and he underwent surgical resection without any complications. The histological diagnosis was adrenocortical carcinoma according to the criteria of Weiss. Following surgical removal of the androgen-producing tumor, the patient subsequently developed hypothalamic-pituitary activation and demonstrated central precocious puberty. He was treated with a gonadotropin-releasing hormone agonist in order to delay further pubertal progression. Clinical follow-up of potential secondary effects of excess hormone secretion after removal is important in some pediatric patients with virilizing adrenocortical tumor.
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Banco de datos:
MEDLINE
Asunto principal:
Pubertad Precoz
/
Neoplasias de la Corteza Suprarrenal
/
Carcinoma Corticosuprarrenal
/
Sistema Hipotálamo-Hipofisario
Límite:
Child
/
Female
/
Humans
/
Male
Idioma:
En
Año:
2009
Tipo del documento:
Article