Radical prostatectomy for high-risk prostate cancer: biochemical outcome.
Int J Urol
; 16(9): 733-8, 2009 Sep.
Article
en En
| MEDLINE
| ID: mdl-19674167
ABSTRACT
OBJECTIVES:
To determine the biochemical outcome following radical prostatectomy alone in patients with high-risk prostate cancer.METHODS:
Between January 2002 and August 2007, 252 patients underwent radical retropubic prostatectomy. Those who received neoadjuvant hormone therapy were excluded from this analysis. Based on pre-operative data, we stratified the patients into low, intermediate, and high-risk groups according to the risk criteria of the National Comprehensive Cancer Network in 2003, respectively. Prostate-specific antigen (PSA) failure was defined as any detectable PSA level higher than 0.2 ng/mL.RESULTS:
The PSA failure-free survival rate for the high-risk group (n = 46) was 64.5% after a median follow-up period of 39 months. Among patients with high-risk disease, none with pathologically organ-confined cancer (n = 19) and a negative surgical margin had PSA failure. The PSA failure-free rate in patients with non organ-confined cancer (n = 27) was 39.5%. Among the pretreatment variables, a positive biopsy core percentage (the number of positive biopsy cores/total biopsy core) >or=30 was a significant independent predictor of extra prostatic extension.CONCLUSIONS:
Radical prostatectomy is feasible in high-risk prostate cancer patients, only if they have a pathologically organ-confined disease.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Próstata
/
Prostatectomía
/
Neoplasias de la Próstata
/
Biomarcadores de Tumor
/
Antígeno Prostático Específico
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Aged
/
Humans
/
Male
/
Middle aged
País como asunto:
Asia
Idioma:
En
Año:
2009
Tipo del documento:
Article