Oxidative stress in brain according to traumatic brain injury intensity.
J Surg Res
; 164(2): 316-20, 2010 Dec.
Article
en En
| MEDLINE
| ID: mdl-19691993
ABSTRACT
BACKGROUND:
The mechanisms of brain damage and neuroplasticity following traumatic brain injury (TBI) are complex and not completely understood. Thus, we investigated markers of oxidative stress in the central nervous system after mild and severe TBI in rats. MATERIAL ANDMETHODS:
Adult male wistar rats (five animals per group) submitted to mild (mTBI group) or severe TBI (sTBI Group) were sacrificed 30 min, 3, 6, or 12 h after the injury to quantify markers of oxidative damage in different brain regions. Levels of thiobarbituric acid reactive species and protein carbonyl in the cortex, hippocampus, striatum, and cerebellum of mTBI and sTBI groups were compared with the control group.RESULTS:
After mTBI, levels of protein oxidation were increased in all analyzed structures in several different times after injury. The increase in TBARS levels was not so consistent in mTBI. In contrast, sTBI did not induce a sustainable increase in oxidative damage markers in all analyzed structures.CONCLUSIONS:
Oxidative damage seemed to be inversely proportional to severity of traumatic brain injury.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Lesiones Encefálicas
/
Estrés Oxidativo
Límite:
Animals
Idioma:
En
Año:
2010
Tipo del documento:
Article