In vivo activity of an islet-reactive T-cell clone.
J Autoimmun
; 3(4): 449-56, 1990 Aug.
Article
en En
| MEDLINE
| ID: mdl-1977404
ABSTRACT
BDC-6.9 is a CD4-positive T-cell clone, specific for NOD islets, which was isolated from the spleen and lymph nodes of a diabetic NOD mouse. The cells were transplanted in a blood clot adjacent to established NOD islet grafts in diabetic (CBA X NOD)F1 recipients. The BDC-6.9 cells initiated extensive damage to the islet grafts, while a non-islet specific clone transplanted adjacent to grafted islets caused no noticeable damage. In addition, the BDC-6.9 cells initiated similar destruction when injected intraperitoneally, suggesting that they may have some migratory capacity. By introducing these islet-reactive cells into the (CBA X NOD)F1, a non-diabetes prone environment, we hope to clarify the role of the islet-specific CD4 cell as related to islet destruction in vivo.
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Banco de datos:
MEDLINE
Asunto principal:
Linfocitos T CD4-Positivos
/
Islotes Pancreáticos
Tipo de estudio:
Etiology_studies
Límite:
Animals
Idioma:
En
Año:
1990
Tipo del documento:
Article