MicroRNA 125a and its regulation of the p53 tumor suppressor gene.
FEBS Lett
; 583(22): 3725-30, 2009 Nov 19.
Article
en En
| MEDLINE
| ID: mdl-19818772
ABSTRACT
MicroRNA (miRNA) are a class of non-coding RNA that suppress gene expression by degradation or translational inhibition of target RNA. Several miRNA have been shown to target oncogenes and recently miRNA-125b was shown to translationally and transcriptionally inhibit the p53 gene. Here, we show that an additional isomer of miRNA-125 (miRNA-125a) translationally arrests mRNA of the p53 tumor suppressor gene. The basis of this activity is the high degree of sequence homology between the seed sequence of miR-125a and the 3'-UTR of p53. Our findings add miRNA-125a to the growing list of miRNA with oncogenic targets.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Regulación de la Expresión Génica
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Proteína p53 Supresora de Tumor
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MicroARNs
Límite:
Humans
Idioma:
En
Año:
2009
Tipo del documento:
Article