DNA variants of alpha-1-antitrypsin in rheumatoid arthritis with and without pulmonary complications.

Bate, A S; Sidebottom, D; Cooper, R G; Loftus, M; Chattopadhyay, C; Grennan, D M

Bate, A S; Sidebottom, D; Cooper, R G; Loftus, M; Chattopadhyay, C; Grennan, D M.

Bate AS; Rheumatic Diseases Centre, Hope Hospital, Salford, Manchester, U.K.

Dis Markers ; 8(6): 317-21, 1990.

Article en En | MEDLINE | ID: mdl-1983194

ABSTRACT

ABSTRACT

Restriction fragment length polymorphisms (RFLPs) of alpha-1-antitrypsin were studied in 99 subjects with rheumatoid arthritis alone, 21 subjects with rheumatoid arthritis and pulmonary fibrosis, 26 subjects with rheumatoid arthritis and bronchiectasis, and 86 controls. No associations with either rheumatoid arthritis itself or with the associated pulmonary disorders were noted in this U.K. Caucasoid population.

Asunto(s)

Artritis Reumatoide/genética; Bronquiectasia/genética; Polimorfismo de Longitud del Fragmento de Restricción; Fibrosis Pulmonar/genética; alfa 1-Antitripsina/genética; Alelos; Artritis Reumatoide/complicaciones; Bronquiectasia/etiología; Predisposición Genética a la Enfermedad; Humanos; Fenotipo; Fibrosis Pulmonar/etiología; Deficiencia de alfa 1-Antitripsina

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Banco de datos: MEDLINE Asunto principal: Artritis Reumatoide / Fibrosis Pulmonar / Polimorfismo de Longitud del Fragmento de Restricción / Bronquiectasia / Alfa 1-Antitripsina Tipo de estudio: Etiology_studies Límite: Humans Idioma: En Año: 1990 Tipo del documento: Article

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