Raloxifene and body composition and muscle strength in postmenopausal women: a randomized, double-blind, placebo-controlled trial.
Eur J Endocrinol
; 162(2): 371-6, 2010 Feb.
Article
en En
| MEDLINE
| ID: mdl-19884264
ABSTRACT
OBJECTIVE:
To compare the effects of raloxifene and placebo on body composition and muscle strength.DESIGN:
Randomized, double-blind, placebo-controlled trial involving 198 healthy women aged 70 years or older conducted between July 2003 and January 2008 at the University Medical Centre, Utrecht, The Netherlands.METHODS:
Participants were randomly assigned to receive raloxifene 60 mg or placebo daily for 12 months. Measurements were taken at baseline, 3, 6, and 12 months, and change from baseline was calculated. Main outcome measures were body composition (bioelectrical impedance analysis), muscle strength, and muscle power (maximum voluntary isometric knee extension strength, explosive leg extensor power, and handgrip strength).RESULTS:
At 12 months, the body composition of women taking raloxifene was significantly different from that of women taking placebo fat-free mass (FFM) had increased by a mean of 0.83 (2.4) kg in the raloxifene group versus 0.03 (1.5) kg in the placebo group (P=0.05), and total body water had increased by a mean of 0.6 (1.8) litres in the raloxifene group versus a decrease of 0.06 (1.1) litres in the placebo group (P=0.02). Muscle strength and power were not significantly different.CONCLUSION:
Raloxifene significantly changed body composition (increased FFM; increased water content) compared with placebo in postmenopausal women.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Composición Corporal
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Osteoporosis Posmenopáusica
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Clorhidrato de Raloxifeno
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Conservadores de la Densidad Ósea
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Fuerza Muscular
Tipo de estudio:
Clinical_trials
Límite:
Aged
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Aged80
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Female
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Humans
Idioma:
En
Año:
2010
Tipo del documento:
Article