Molecular analysis and prognostic impact of the novel apoptotic gene BCL2L12 in gastric cancer.
Biochem Biophys Res Commun
; 391(1): 214-8, 2010 Jan 01.
Article
en En
| MEDLINE
| ID: mdl-19903463
ABSTRACT
Stomach cancer comprises a malignancy with feeble prognosis. In gastric carcinogenesis, molecular alterations in the apoptosis-related genes have been described. In this study, the expression of BCL2-like-12 (BCL2L12) gene, discovered and cloned by members of our group, was investigated in a statistically significant sample size of cancerous and non-cancerous stomach tissues and gastric cancer cells with quantitative real-time PCR methodology. BCL2L12 transcript was indicated in cancer gastric tissues to range from 29 to 53200 mRNA copies BCL2L12/10(6) mRNA copies GAPDH. Significant associations of BCL2L12 with gastric tumors of the early stages (I/II) (p=0.044) and of intestinal histotype (p=0.034) was substantiated. Both univariate and multivariate analyses disclosed, respectively, BCL2L12 relationship with disease-free (p=0.006 and p=0.025) and overall patients' survival (p=0.007 and p=0.022). Our results open new horizons for the possible application of BCL2L12 as a novel prognostic indicator of gastric cancer.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias Gástricas
/
Biomarcadores de Tumor
/
Regulación Neoplásica de la Expresión Génica
/
Proteínas Proto-Oncogénicas c-bcl-2
/
Proteínas Musculares
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Año:
2010
Tipo del documento:
Article