[Molecular diagnosis of liposarcomas: identification of the chimeric genes FUS/CHOP and EWS/CHOP].
Arkh Patol
; 71(5): 32-5, 2009.
Article
en Ru
| MEDLINE
| ID: mdl-19938700
ABSTRACT
This paper presents the results of an analysis the chimeric genes FUS/CHOP and EWS/CHOP in patients diagnosed as having liposarcoma in order to make a differential diagnosis in both soft tissue tumors and various variants of liposarcoma. Liposarcomas were found in 5 of 7 cases of primary tumors 4 chimeric transcripts of the FUS/CHOP type (5-2), a variant of alternative splicing of the FUS/CHOP type (5-2) with depletion in 14 p.n. anda rare variant of the EWS/CHOP type (7-2). Fluorescence in situ hybridization (FISH) confirmed translocations in the tumor samples with the chimeric genes being detected. Reverse transcription-polymerase chain reaction and FISH revealed no chimeric genes specific to myxoid sarcoma in a group of patients with other variants of liposarcoma. Thus, the findings support the strict specificity of the chimeric genes FUS/CHOP and EWS/CHOP for myxoid liposarcoma and the expression of these genes in most tumors of this type.
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Banco de datos:
MEDLINE
Asunto principal:
ARN Mensajero
/
ARN Neoplásico
/
Regulación Neoplásica de la Expresión Génica
/
Proteínas de Fusión Oncogénica
/
Proteína EWS de Unión a ARN
/
Proteína FUS de Unión a ARN
/
Factor de Transcripción CHOP
/
Liposarcoma
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Ru
Año:
2009
Tipo del documento:
Article